Presenter
Jaelyn Holt
Document Type
Poster
Publication Date
2026
Abstract
Mast Cell Activation Syndrome (MCAS) is a rare disorder where inappropriate activation of mast cells causes an allergic inflammatory reaction. This project examined the immunological aspect of MCAS, clinical manifestations, current diagnostic approaches, therapies, and future directions for research. MCAS is recognized as a distinct clinical entity identified by inappropriate or excessive activation of mast cells, rather than increased cell proliferation. Mast cells are an important in the innate immune system and play a role in immune system responses such as allergic reactions, tissue repair, neuroimmune signaling, and the elimination of bacteria. Mast cell hyperactivation leads to the release of mediators and chronic, often multi-system symptoms. The project revealed that clinical presentations and symptomology vary widely and can include dermatologic, gastrointestinal, cardiovascular, and neurologic manifestations, contributing to the misdiagnosis of MCAS. Diagnosing is challenging due to limitations including a lack of definitive biomarkers, challenges in assay standardization and timing, and variability in testing protocols for mediators released during mast cell activation. Symptom control is the current clinical standard, instead of disease modification, so therapies include antihistamines, mast cell stabilizers, and leukotriene inhibitors. The project detailed limitations in research, current diagnostic challenges, and future directions for diagnosis and treatment.
Faculty Mentor
Nicole Urban, Ph.D.
Academic Discipline
College of Arts & Sciences
Repository Citation
Holt, Jaelyn, "Discovering Mast Cell Activation Syndrome" (2026). Student Research Design & Innovation Symposium. 276.
https://scholarsarchive.jwu.edu/innov_symposium/276
